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Submitted April 3, 2007
Tramadol is for oral use only, as powder from a crushed tablet should not be diluted or even inhaled with liquid and injected into the patient’s body. Using Tramadol by inhalation or injection can critically cause overdose, life-threatening side-effects or even death. It has been reported that seizures can be a side affect in some people who take Tramadol. If you have a history of seizures or head injury, a metabolic disorder or taking antidepressants, nausea medicine or muscle relaxers, then a seizure may take place when taking Tramadol. It’s significant to seek emergency medical attention if you think you have overdosed on Tramadol—a Tramadol overdose can be extremely fatal. Tramadol overdose symptoms may include slow heartbeat, shallow breathing, drowsiness, cold or clammy skin, coma, fainting, extreme weakness or feeling light-headed. While taking Tramadol, do not use drugs (cold medicine, muscle relaxants) or drink alcohol that make you sleepy. These drugs may increase drowsiness or slow breathing when mixed with Tramadol. Tramadol can cause adverse effects which may impair reactions or thinking.
It’s crucial to know that Tramadol may be injurious to an unborn baby. Tramadol may even cause fatal side-effects in a newborn if the mother uses the medication during the pregnancy stage or labor. A woman should telephone her physician if she is pregnant or plan to become pregnant during Tramadol treatment. Tramadol can get into breast milk and may even damage a nursing baby. It’s important not to use Tramadol without alerting the physician if breast-feeding a baby. Tramadol should always be used with extreme caution in patients with increased intracranial pressure or even head injury. The respiratory depressant effects of opioids include secondary elevation of cerebrospinal fluid pressure and carbon dioxide retention, and may be exaggerated in the patients. Moreover, mitosis from Tramadol may mask the extent, existence or intracranial pathology. Physicians and clinicians should maintain a high index of suspicion for unfavorable drug reaction when evaluating reworked mental status in patients receiving Tramadol.
Tramadol decreases pain intensity, produces symptom relief and improves function—although the benefits are somewhat miniscule. This is the main reason participants stop taking Tramadol, which could limit the usefulness of this medication. Research shows that individuals who received Tramadol had a 37% increase in the likelihood of reporting moderate improvement. Individuals receiving Tramadol may have more chance of side-effects than those who use the placebo medication. However, the benefits of Tramadol in patients will usually outweigh those of placebo in patients.
Tramadol may induce physical and psychic dependence of the morphine-type. Abuse and dependence—which includes drug-seeking behavior and enforcing illicit actions to acquire the drug—are not limited to patients with prior history of opioid dependence. The risk in patients with substance abuse has been observed to be much higher. Tramadol is normally associated with craving and tolerance development. Normally, withdrawal symptoms occur when discontinued expediently. Symptoms usually are insomnia, sweating, anxiety, pain, nausea, rigors, tremors, diarrhea, piloerection, upper respiratory symptoms, and ofttimes hallucinations. Clinical experience suggests withdrawal symptoms may be reduced by reinstitution of opioid therapy followed by a tapered, gradual dose reduction of Tramadol combined with symptomatic support.
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